Amide Compound with Inhibitory activity of FAAH, a method for its preparation and Neuroprotective Agents for Treatment or prophylaxis of cerebrovascular disorders.

摘要

It provides a FAAH inhibitor and an agent for the prophylaxis or Therapy of cerebrovascular Disorders and Sleep Disorders that comprise it.Claim 1: a compound characterized by being represented by the formula (1) wherein z is o or s, R1 can be substituted aryl or Heterocyclic Group, which can be replaced; A1A is a H Atom, a Hydrocarbon group which may be substituted hydroxyl, alkoxyl, PU Can be replaced, ariloxilo amino can be replaced, which can be replaced,Cicloamino saturated or 5 to 7 members can be replaced; R2 is piperidin 1.4 - dilaurate which can be replaced, or piperazin - 1.4 - dilaurate which can be replaced; R3 is a group formed by removing two H Atoms and an Aromatic Heterocyclic Group of 5 members who has 1 3 heteroatoms s Selected n, o and S can also be replaced, co -- CO or co NH -; and R4 is a Hydrocarbon group which may be replaced, or a Heterocyclic Group can be replaced, with the condition that when R3 is co, co or co - or - NH -, R1 is benzoisoxazolilo (with the condition; n - (4-fluorophenyl) - 4 - [5 - (4-fluorophenyl) - 4 - pyridin-4-yl - 1H pyrazole - 3 - il 1) piperidin - carboxamide,N - phenyl 4 - (4 - [3 - (trifluoromethyl) phenyl] - 1H imidazole piperidin yl) - 2 - 1 - carboxamide and 4 - [4 - (4-methylphenyl) - 5 - (2 - [2 - (trifluoromethyl) pyrimidin-4-yl) methyl) pyrimidine - 5 - il) - 1H imidazol-1-yl] - N - [3 - (trifluoromethyl) phenyl] - carboxamide piperidin 1 are excluded), or a Salt thereof.Claim 21 that is characterized by: a procedure to produce a compound of formula (2) where R1 is that can be substituted aryl or Heterocyclic Group, which can be replaced; R4 is a Hydrocarbon group which may be replaced, or a Heterocyclic Group that can be Replaced; X is o or s; e and N or C, or a Salt thereof,That includes subjecting a ureidacion reaction of a compound of formula (3), wherein each symbol is as defined above, or a Salt thereof.