Derivatives of (1,2,4) - ditiazoli (DI), inductors, glutathione-s-transferase and NADPH quinone oxide reductase, for prophylaxis and Treatment of adverse conditions associated with cytotoxicity and apoptosis in particular in general

摘要

It also relates to the use of a compound described in the present for the manufacture of a Medicament useful for the prophylaxis and Treatment of adverse conditions associated with cytotoxicity and apoptosis in general in particular.Claim 2: compounds of the General formula (1) wherein the dotted Lines between the C Atom Number 5 and its neighbouring Atoms of n links represent single or double, with the condition that one of the two Links is a simple Link and one is a double Bond, with the condition that When the double bond is between the C Atom and N Atom Number 5, Number 4,R4 there and when the double bond is between the C Atom and N Atom Number 5 of the exo, r2no exists; R1, R2, R3 and R4 independently represent an alkyl group c1-4 branched or unbranched, optionally containing sulfoxide s Atoms or groups, amide, ketone, or sulfon tiocetona A, and is optionally substituted halogeno, cyano, mono - or dialkyl C1 - 4amino, trifluoromethyl,C1-4 alkoxy or hydroxyl, or R1 and R2 together with the N Atom which are United to form a system of rings, 4 to 8 members which may be present in other heteroatoms (substituted) chosen of N, o and S, and the system of rings which can be optionally substituted alkyl C 1 - 4, branched or unbranched, halogeno, cyano, mono - or dialkyl C1 - 4amino, trifluoromethyl,The hydroxyl or alkoxy c1-4 which Ring system contains functions tiocetona, amide, ketone sulfone or sulfoxide, R3 represents h, alkyl, c1-4, branched or unbranched, optionally containing sulfoxide s Atoms or groups, amide, ketone, tiocetona or sulfone, and optionally its Replace with mono halogeno, cyano, trifluoromethyl or dialkyl C1 - 4amino, c1-4 alkoxy, c1-4 alkyl, S,Sh or hydroxyl Group, and R3 represents an optionally substituted aryl, alkyl groups with branched or unbranched c1-4 alkyl, aryl, C1 - 4arilo s, sh, c1-4 alkyl, halogeno, cyano, mono - or dialkyl C1 - 4amino, CF3, ocf3, scf3 Hydroxy or alkoxy, Nitro, C1 - 4, and - tautomeros, stereoisomers Oxides thereof, and pharmacologically acceptable salts,Hydrates and solvates of said compounds of formula (1) and its tautomeros, stereoisomers and N - oxides.