Method for Preparation of fluoro naftalen - 8 - 1 - ilamina and use this to obtain a favorable Synthesis of 7 - (4 - 4 - (5 - fluoro - naftalen - 1 - il) piperazin-1-yl - Butoxy} - 3, 4 - dihydro 1H - 1, 8 naftiridin - 2 - ona

摘要

Describes a procedure for the preparation of fluoro naftalen - 8 - 1 - ilamina comprising reacting 1H - Naphtho [1,8] - [1,2,3] triazine with Hydrogen fluoride or a complex of hydrogen fluoride and a base n donor.It also suggests a procedure to use 8 - fluoro naftalen - 1 - ilamina produced as described above for the preparation of 1 - (5 - fluoro - naftalen - 1 - il) - piperazine can be used as an intermediate in the production of 7 - (4 - [4 - (8 - fluoro naftalen - 1 - IL) - piperazin.Il - 1} - butoxy] - 3,4-dihydro - 1H - [1,8] naftiridin - 2 - ona, a partial D2 agonist indicated for possible use in the treatment of schizophrenia.