Preparation method of (3-chloro-4-fluorophenyl) - (4 - (5 fluoro - 4 - methyl - 2 - methyl - pyrimidin-2-yl) - amino methyl - piperidin-1-yl) - methanone Derivatives of pyrimidine compounds and Intermediates

摘要

This is a method to prepare (3-chloro-4-fluorophenyl) - ((4 - (4 - [(fluoro - 5 - methyl - 2 - methyl - pyrimidin-2-yl) - amino] - amino] methyl} - piperidin-1-yl) - methanone, formula (1), condensation between 5 - methyl - 2 - methylamine pyrimidine of formula (2), and cyanohydrin of formula (3). Claim 1: 5 - methyl - 2 - amino pyrimidine of formula (2).Claim 1: The pyrimidine Derivatives of formula (4), where the Radicals R1 and R2 independently represent a hydrogen Atom or a group or a Group benciloxicarbonilo tert butiloxicarbonilo; where R1 and R2 together with the atom of nitrogen Carrier form a phthalimido Group. Claim 1: The pyrimidine Derivatives of formula (5) to (7).