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n- phenyl (pyrrolidin-2-yl) methyl benzamide and n - (azepan-2-yl) phenylmethyl benzamide derivatives, preparation and application thereof in therapy
n- phenyl (pyrrolidin-2-yl) methyl benzamide and n - (azepan-2-yl) phenylmethyl benzamide derivatives, preparation and application thereof in therapy
"N-PHENYL (PYROLIDINE-2-IL) METHODS! BENZAMIDE AND N- (AZEPAN-2-IL) PHENYLMETHYLE BENZAMIDE, PREPARATION OF THEME AND APPLICATION THERAPY". The present invention relates to compounds of formula (1) wherein n is 1 or 3, R1 is H, cycloalkyl, cycloalkylalkyl, phenylalkyl, alkenyl, alkynyl, X is H are one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, R 2 is H, or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl, alkoxy, cycloalkyl groups , phenyl, cyano, acetyl, benzoyl, S-alkyls, alkylsulfonyls, carboxy and alkoxycarbonyls, be a group of formula NR 3 R 4, SO 2 NR 3 R 4 or CONR 4 Wherein R3 and R4 each represent H or an alkyl or cycloalkyl group or form, with the nitrogen atom, a pyrrolidine, piperidine or morpholine cyclo. Application in therapy.
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机译：“ N-苯基（吡咯烷-2-IL）方法！苯甲酰胺和N-（AZEPAN-2-IL）苯甲基苯甲酰胺，主题的制备和应用疗法”。本发明涉及式（1）的化合物，其中n是1或3，R 1是H，环烷基，环烷基烷基，苯基烷基，烯基，炔基，X是H是选自卤素原子和三氟甲基，烷基和烷氧基的一个或多个取代基。 R 2是H，或选自卤素原子和三氟甲基，烷基，烷氧基，环烷基，苯基，氰基，乙酰基，苯甲酰基，S-烷基，烷基磺酰基，羧基和烷氧羰基的一个或多个取代基，是式NR的基团3 R 4，SO 2 NR 3 R 4或CONR 4其中R3和R4分别代表氢或烷基或环烷基或与氮原子形成的吡咯烷，哌啶或吗啉环。在治疗中的应用。
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