首页> 外国专利> Prodroga compound, a compound, the function of the receptor modulator GPR40, agent pharmaceutical, use of a compound and methods of modification of a function of the receiver GPR40 in a mamu00ecfero,Prophylaxis or treatment of diabetes in a mamu00ecfero and production of a compound

Prodroga compound, a compound, the function of the receptor modulator GPR40, agent pharmaceutical, use of a compound and methods of modification of a function of the receiver GPR40 in a mamu00ecfero,Prophylaxis or treatment of diabetes in a mamu00ecfero and production of a compound

机译:Prodroga化合物,一种化合物,受体调节剂GPR40的功能,药物制剂,该化合物的用途和修饰受体GPR40在哺乳动物中的功能的方法,预防或治疗哺乳动物的糖尿病和生产一种化合物

摘要

"Prodroga compound, a compound, the function of the receptor modulator GPR40, agent pharmaceutical, use of a compound and methods of modification of a function of the receiver GPR40 in a mamu00ecfero,Prophylaxis or treatment of diabetes in a mamu00ecfero and production of a compound.The present invention provides a novel compound represented by formula (I) where each symbol is as defined in the description.A salt of the same, and a prodroga of presenting a superior function of the receptor modulating action of GPR40, that can be used as a secretagogo insulin.An agent for the prophylaxis or treatment of diabetes, and similar.They exhibit unexpectedly superior GPR40 receptor agonist activity, and also have superior properties as a pharmaceutical product, such as stability and the like.Thus, they can be safe and useful pharmaceutical agents for the prophylaxis or treatment of diseases related to GPR40 receptor in mammals.
机译:Prodroga化合物,一种化合物,受体调节剂GPR40的功能,药物制剂,该化合物的用途以及修饰受体GPR40在哺乳动物中的功能的方法,在哺乳动物中的糖尿病的预防或治疗本发明提供了由式(I)表示的新颖化合物,其中每个符号如说明书中所定义。其盐,以及显示出GPR40的受体调节作用的优异功能的前驱体。可以用作分泌胰岛素的药物。用于预防或治疗糖尿病等的药物,它们具有出乎意料的GPR40受体激动剂活性,并且还具有作为药品的优异性能,例如稳定性等。 ,它们是预防和治疗哺乳动物GPR40受体相关疾病的安全有效的药物。

著录项

  • 公开/公告号BRPI0418148A

    专利类型

  • 公开/公告日2007-04-17

    原文格式PDF

  • 申请/专利权人 TAKEDA PHARMACEUTICAL COMPANY LIMITED;

    申请/专利号BR2004PI18148

  • 申请日2004-12-24

  • 分类号C07D309/12;C07C59/68;C07C59/72;C07C69/734;C07C205/34;C07C205/35;C07C217/20;C07C233/11;C07C233/18;C07C309/66;C07C317/18;C07C323/12;C07D207/08;C07D207/26;C07D207/27;C07D213/30;C07D277/24;C07D295/092;C07D295/18;C07D295/185;C07D295/205;C07D305/06;C07D333/32;C07D333/34;C07D335/02;C07F7/18;C07F9/40;

  • 国家 BR

  • 入库时间 2022-08-21 20:59:25

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