process of obtaining synthetic and semi-synthetic derivatives of lignans, their antiparasitic activities and their pharmaceutical formulations, encompassing the therapeutic method using such lignans in the treatment of parasitic diseases.

摘要

"PROCESS FOR OBTAINING SYNTHETIC AND SEMISINTETIC DERIVATIVES OF LIGNAN, ITS ANTIPARASITARY ACTIVITIES AND THEIR PHARMACEUTICAL FORMULATIONS, ENGAGING THERAPEUTIC METHOD USING SUCH PARTAALS". The present invention relates to a process for obtaining synthetic and semi-synthetic lignan derivatives, in particular dibenzylbutyrolactonic, tetrahydrofuran, aryltetraline, furofuran and dibenzocyclooctanic lignans obtained by partial synthesis and / or total isolation. from plant extracts. Refers to a process for obtaining synthetic and semi-synthetic cubebin derivatives such as: (-) - O-acetyl cubebin; (-) - Omethyl cubebin; (-) - O-N, N- (dimethylamino-ethyl) -cuboline; (-) - hyinoquinine; (-) - 6.6? Dinitroinoquinine; (-) - O-benzyl cubebin; (-) - 6-6 39 -diaminoinoquinine, (-) - 6-6 39 dinitroinoquinine, as well as obtaining dibenzocyclooctanic lignans from dibenzylbutyrolactonic lignans by structural changes at positions 7, 7 39, 8 , 8 39, 9 39 and aromatic rings (introduction and / or substitution of functional groups such as: -OH, CO ~ 2 ~ H, -CO ~ 2 ~ CH ~ 3 ~, -NO ~ 2 ~, -NH ~ 2 ~, -OCH ~ 3 ~, -OAc, -SO ~ 2 ~ CH ~ 3 ~, -SO ~ 2 ~ NH ~ 2 ~, prenyl and halogens). The invention also relates to a therapeutic method since the described substances are used in the manufacture of medicaments which provide antiparasitic activity.