bispecifically binding molecule, nucleic acid sequence, vector, process for the production of bispecifically binding molecule, composition, use of bispecifically binding molecule in the preparation of the pharmaceutical composition, and kit

摘要

Biospecific Binding Molecule, NUCLEIC ACID SEQUENCE, VECTOR, PROCESS FOR PRODUCING Biospecific Binding Molecule, COMPOSITION, USE OF BISPECIFIC Binding Molecule In The PREPARATION OF THE SPECIFIC PREPARATION BULLET The molecule comprises or consists of at least two domains, wherein one of said at least two domains specifically binds to / interacts with the human CD3 complex and said domain comprises an antibody-derived short chain amino acid sequence, wherein said sequence Amino acid sequence is a particularly identified amino acid sequence comprising specific amino acid substitutions, and a second domain that is or contains at least one antigen-interacting site and / or at least one additional effector domain. The invention further provides nucleic acid molecules encoding bispecific binding molecules of the invention, vectors comprising said nucleic acid molecules and host cells transformed or transfected with said vectors. Further, the invention relates to a method for producing the bispecific binding molecules of the invention and compositions comprising the bispecific binding molecules of the invention, the nucleic acid molecules of the invention or the host cells of the invention.