method for the regiospecific synthesis of a rapamycin 42-hemiester or a fk-506 32-hemiester with a dicarboxylic acid, regiospecific rapamycin 42-hemiester, rapamycin antibody, product, and fk506 regiospecific 32-hemiester

摘要

Method for the Regiospecific Synthesis of a 42-HEMIESTER RAPAMICIN OR 32-HEMIESTER OF FK-506 WITH A DICARBOXYLIC ACID, 42-HEMIESTER OF RAPAMICIN RAPAMYCIN, 32-HAPESISPHERICINE RAPAMICIN, Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids are described. The methods involve catalyzing the reaction between a rapamycin or an FK-506 and a dicarboxylic anhydride or an activated bifunctional dicarboxylic acid ester with a lipase.