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Controlled release Pharmaceutical compositions comprising Polymers loaded with dida and exten

机译:控释药物组合物,其包含载有dida和exten的聚合物

摘要

1. Bioadhesive drug ingredients, including an ion therapeutic agent and an ion polymer, in which the polymer has enough ionization property to provide ions together with the therapeutic agent, so that the ingredients can release the therapeutic agent in a controlled manner for a long time, When the composition does not need a latex system, it can be used for the composition required in 2-1 of the treatment medium, wherein the polymer is anion 3-1, wherein the polymer is ion;The composition also includes a biological adhesive, 4. The composition required in Item 2, wherein the therapeutic agent is anionic, and the composition also includes a complex blinding agent, which forms a complex structure with the therapeutic agent, and its complexity is combined with the anionic polymer. When the polymer is sufficiently ionized to combine with the angular compound, it can also provide biological bonding of the components. 6. The composition of claim 2, wherein the polymer is sufficiently ionized to provide biological bonding.In the case that the polymer is a polycarbonate polymer extracted from a biological adhesive, it is mixed with water but insoluble in water. 8. The composition required in Item 7, wherein the polymer includes polycarbonate 9. In this case, release one treatment agent at least 6 hours and 10 minutes; in this case, release the components required in Item 2 for at least 12 hours.
机译:1.生物粘附性药物成分,包括离子治疗剂和离子聚合物,其中该聚合物具有足够的电离性质以与治疗剂一起提供离子,从而使这些成分可以长期以受控方式释放治疗剂。当该组合物不需要胶乳体系时,可用于处理介质2-1中所需的组合物,其中聚合物为阴离子3-1,其中聚合物为离子;该组合物还包括生物粘合剂,4.项2中要求的组合物,其中治疗剂是阴离子的,并且该组合物还包含复合盲剂,其与治疗剂形成复杂的结构,并且其复杂性与阴离子聚合物结合。当聚合物被充分离子化以与角化合物结合时,它还可以提供组分的生物键合。 6.权利要求2的组合物,其中所述聚合物被充分离子化以提供生物键合。在所述聚合物是从生物粘合剂中提取的聚碳酸酯聚合物的情况下,其与水混合但不溶于水。 8.项目7所要求的组合物,其中所述聚合物包括聚碳酸酯。9.在这种情况下,释放一种处理剂至少6小时10分钟;然后释放一种处理剂。在这种情况下,请释放项目2中所需的组件至少12个小时。

著录项

  • 公开/公告号CO5700711A2

    专利类型

  • 公开/公告日2006-11-30

    原文格式PDF

  • 申请/专利权人 COLUMBIA LABORATORIES (BERMUDA) LIMITED;

    申请/专利号CO20050047639

  • 发明设计人 BOLOGNA WILLIAM J.;

    申请日2005-05-17

  • 分类号A61K;A61K9;A61K9/20;A61K9/22;A61K9/70;A61K31;A61K31/137;A61K31/192;A61K31/245;A61K31/554;A61K47/32;A61P;

  • 国家 CO

  • 入库时间 2022-08-21 20:59:12

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