Process for preparing fine crystalline mixture containing non-steroidal antiphlogistic medicament, fine crystalline mixture prepared in such a manner that, and solid pharmaceutical composition comprising such fine crystalline mixture

摘要

solve the concerns the way of gently crystalline smesi containing non steroidal protizu00e1netlivu00e9 lu00e9civo and excipients.in which rough crystalline substance of non steroidal protizu00e1netlivu00fdch lu00e9civ for zvu00fdsenu00e9 temperature dissolved in rozpoustedle,potu00e9se solution for rapid cooling of the coolant is distributed to containing excipients and umu00edstenu00e9 in ice bath, nacez product prefiltruje and vysusu00ed.also includes the crystalline mixture gently steroidal protizu00e1netlivu00e9ho lu00e9civa and excipients ready that way.also includes a solid pharmaceutical had a reporting vu00fdznamne zlepsenu00e9 characteristics in disoluci,which contains 60 to 78% by weight of crystalline smesi steroidal protizu00e1netlivu00e9ho lu00e9civa gently with the excipient according to this invention, 17 to 40% by weight of microcrystalline cellulose.colloidal kremicitu00fd in mnozstvu00ed az to 0,3% by weight and rozvolnovadlo in mnozstvu00ed% to 4% hmotnostnu00edch., popru00edpade povrchove active substance in mnozstvu00ed to 0.1 (w / w) %.this solid pharmaceutical had plnen into capsules or can be used for the preparation of tablets.