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Process for the preparation of compressed solid dosage forms suitable for use with low water solubility drugs and compressed solid dosage forms prepared thereby
Process for the preparation of compressed solid dosage forms suitable for use with low water solubility drugs and compressed solid dosage forms prepared thereby
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机译:适于与低水溶性药物一起使用的压缩固体剂型的制备方法和由此制备的压缩固体剂型
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摘要
A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about (25) weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.
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