DEVICE FOR LOCAL ADMINISTRATION OF SOLID AND SEMISOLID FORMULATIONS, SUSTAINED-RELEASE FORMULATIONS FOR PARENTERAL ADMINISTRATION AND METHOD OF PREPARATION

摘要

The invention concerns the use, for implanting or inserting a solid (1, 9) or semisolid (18) formulation, for being set in a precise receptor site (T) of the system, containing at least one active principle, said formulation being of a solid or semisolid consistency such that it can remain for some time in the site, and containing a limited dose of active principle for treatment in a targeted zone of the body, a device comprising one part set inside the body of the patient with means for conditioning the solid or semisolid form, positioning means for bringing these conditioning means to the deposit site, means for injecting or inserting in this deposit site, means for removal after injection or insertion, and one part remaining outside with means for activating the functions of the device. The invention also concerns a sustained-release solid formulation for parenteral administration containing a homogeneous mixture of an active principle in non-dispersed state and of a biologically compatible and biodegradable excipient, in which the amount of active principle is at least 50 % by weight.