REVERSED PHASE CHROMATOGRAPHIC SEPARATION OF EPOTHILONES A AND B, TWO CRYSTALLINE FORMS OF EPOTHILONE B AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.