PEPTIDES FOR TREATMENT OF THE HUMAN PAPILLOMAVIRUS (HPV)-ASSOCIATED CANCER AND OTHER EPITHELIAL TUMORS

摘要

The invention relates to peptides that are used to treat epithelial tumours and, specifically, those associated with oncogenic types of the Papilloma Virus (HPV). The invention also relates to the identification of peptides having a structure that enables the blocking of the phosphorylation domain by casein kinase II (CKII) by means of direct interaction with said site. According to the invention, eleven peptides are used which have a cyclical structure and different amino acid sequences. Said peptides: inhibit the phosphorylation site by in vitro CKII; produce cytotoxicity in carcinoma cells in the neck of the human uterus which are transformed by HPV-16 (CaSki); and increase the sensitivity of said cells to the cytostatic effect of interferon (IFN). The invention also relates to the use of said peptides which are conjugated or fused to other peptides and chemical compounds with intracellular penetration. Moreover, the invention relates to the use of mimic molecules of peptide and chemical origin.