A once a day buoyant gas powered matrix composition in the form of a tablet for oral administration in mammals for controlled release of ciprofloxacin which comprises ciproflaxin, from 5 to 40% by wt of a gas evolving agent and from 0.5 to 10% by wt of a binder, the balance consisting of pharmaceutically acceptable excipients, said composition having been granulated by a wet granulating process and compressed into tablets.
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