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AN ANTIBODY OR ANTIGEN-BINDING PORTION THEREOF WHICH BINDS TO BACILLUS ANTHRACIS PROTECTIVE ANTIGEN
AN ANTIBODY OR ANTIGEN-BINDING PORTION THEREOF WHICH BINDS TO BACILLUS ANTHRACIS PROTECTIVE ANTIGEN
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机译:与其结合的芽孢杆菌保护性抗原的抗体或抗原结合部分
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摘要
: Isolated human monoclonal antibodies which bind to Anthrax protective antigen are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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