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QUINALDINE BASED SEMISQUARAINES AND SSQUARAINE DYES, A PROCESS FOR THE PREPARATION THEREOF AND THEIR USE AS SENSITIZERS FOR PHOTODYNAMIC THERAPEUTICAL AND INDUSTRIAL APPLICATIONS
QUINALDINE BASED SEMISQUARAINES AND SSQUARAINE DYES, A PROCESS FOR THE PREPARATION THEREOF AND THEIR USE AS SENSITIZERS FOR PHOTODYNAMIC THERAPEUTICAL AND INDUSTRIAL APPLICATIONS
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机译:基于奎奴定的半季铵盐和半季铵盐染料的制备方法及其在光热疗和工业应用中作为敏化剂的用途
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摘要
The present invention provides quinaldine-based semisquaraines, symmetrical and unsymmetrical squaraine dyes represented by the general formulae 1, 2 and 3 and /or pharmaceutically acceptable derivatives thereof as sensitizers for photodynamic therapeutical and industrial applications. These symmetrical and unsymmetrical squaraine dyes posses absorption which extends well into the photodynamic window (650-800 nm) and hence are useful for the treatment of deep seated tumors. The absorption of these dyes can be tuned by changing the substituents on the quinaldine moiety thereby enabling the development of a library of dyes which have absorption ranging from 650 to 800 nm. They also exhibited fluorescence emission in the long wavelength region making them useful as near infrared fluorescence sensors for the detection of tumors. These dyes are non-toxic in the dark and exhibit good photocytotoxicity. Accordingly the quinaldine based semisquaraines, symmetrical and unsymmetrical squaraines are extremely useful as diagnostic and therapeutic agents for photodynamic therapeutical and industrial applications.
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