3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES.

摘要

The present invention provides compounds of Formula (I) or (II) salt form or prodrug thereof, wherein variables are. defined herein, that are modulators of metalloprotcascs such as matrix metalloproteases (MMPs) and ADAMs. The compounds or compositions described herein can be used to treat diseases associated with metalloprotease activity including, for example, arthritis, cancer, cardiovascular disorder, skin disorders, inflammation or allergic conditions.