COMBINATIONS OF PYRAZOLE KINASE INHIBITORS AND FURTHER ANTITUMOR AGENTS.

摘要

The invention provides a combination of a compound having the formula (0) and two or more further anti-cancer agents: or salts or tautomers or N-oxides or solvates thereof; wherein X is a group Rsup1/sup-A-NRsup4/sup- or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C=O, NRsup9/sup(C=O) or 0(C=O) wherein Rsup9/sup is hydrogen or Csub1-4/sub hydrocarbyl optionally substituted by hydroxy or Csub1-4/sub alkoxy; Y is a bond or an alkylene chain of 1 , 2 or 3 carbon atoms in length; Rsup1/sup is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a Csub1-8/sub hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, Csub1-4/sub hydrocarbyloxy, amino, mono- or di-Csub1-4/sub hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SOsub2/sub; Rsup2/sup is hydrogen; halogen; Csub1-4/sub alkoxy (e.g. methoxy); or a Csub1-4/sub hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or Csub1-4/sub alkoxy (e.g. methoxy); Rsup3/sup is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and Rsup4 /supis hydrogen or a Csub1-4/sub hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or Csub1-4/sub alkoxy (e.g. methoxy).