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CAPSULE STABLE AGAINST MASTICATION.

机译:胶囊稳定的抗射精。

摘要

Soft capsules being easily disintegratable in the stomach and avoiding any ready leakage of contents at mastication, which soft capsules encapsulate (2R)-2-propyloctanoic acid or its salt and are characterized in that there is realized at least one property, preferably all thereof, selected from among (A) strength of 150 to 400 N as measured by a cracking load test; (B) disintegration time of 3 to 10 min as measured by a disintegration testing method stipulated in Japanese Pharmacopoeia; (C) thickness of 0.05 to 0.50 mm with respect to the central part of capsule shell; (D) thickness of 0.10 to 0.55 mm with respect to the first joint part of capsule shell; (E) thickness of 0.05 to 0.50 mm with respect to the second joint part of capsule shell; and (F) capsule shell water content of 5.0 to 9.0%.
机译:软胶囊易于在胃中崩解并避免咀嚼时内容物立即泄漏,该软胶囊封装了(2R)-2-丙基辛酸或其盐,其特征在于实现了至少一种特性,优选全部特性,选自(A)150-400N的强度,该强度是通过裂化载荷试验测得的; (B)通过日本药典规定的崩解试验方法测得的崩解时间为3至10分钟; (C)相对于胶囊壳的中央部分的厚度为0.05至0.50mm; (D)相对于胶囊壳的第一接合部的厚度为0.10〜0.55mm。 (E)相对于胶囊壳的第二接合部分的厚度为0.05至0.50mm; (F)胶囊壳的水含量为5.0至9.0%。

著录项

  • 公开/公告号MXPA06014396A

    专利类型

  • 公开/公告日2007-03-12

    原文格式PDF

  • 申请/专利权人 ONO PHARMACEUTICAL CO. LTD.;

    申请/专利号MX2006PA14396

  • 申请日2005-06-10

  • 分类号A61K31/20;A61K9/00;A61K9/48;A61K47/00;A61K47/10;A61K47/42;A61P25/00;A61P25/00;

  • 国家 MX

  • 入库时间 2022-08-21 20:57:03

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