Cyanpropene derivatives for single drug preparation, single drug preparation, containing ingredients and processes to produce single drug preparation

摘要

1. A formula compound I, wherein R1 is halogenated, hydroxy, alcox C1-C5, C1-C5 tar, R2 is h, halogenated, hydroxy, alcox C1-C5, and R3 and R4 are h, halogenated, hydroxy, alcox C1-C5, X is O, s, es-cr5r6 -;R5 and R6 are h, halogen, C1-C10 tar substitutes or non substitutes respectively; W is h, the acidity produced by naturally occurring amino acid derivatives; Z is h, C1-C10 tar substitutes or non halogen substitutes, C1-C5 hydroxide compounds, etc. The preferred compound is benzoate (2S, 4S) - 2-cyano-4-fluoro-1 - [(2-hydroxy-1, 1-dimethyl) acetylpyridine. A pharmacological component is also mentioned, which contains a stabilizer selected between sugar and sugar alcohol, reducing the decomposition of the compound,And a preparation procedure. These compounds are the fourth (DPIV) effective inhibitors for the treatment of type 2 diabetes.