Hydantoin derivatives compounds as converting Enzyme inhibitors of tumor necrosis factor alpha (TACE)

摘要

Hydantoin derivatives relates to compounds of formula (a), (b), (c), among others. Also refers to a method of Preparation.These compounds are inhibitors of Matrix Metalloproteinases (MMPs), disintegrin metalloproteases (Adams) and Converting Enzyme of tumor necrosis factor alpha (TACE) by preventing the release of tumor necrosis factor alpha being useful in the treatment of rheumatoid arthritis, escl Multiple erosis, psoriasis, Crohn's disease, systemic lupus erythematosus, asthma