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USE OF SOMATOSTATIN OR ONE OF THE ANALOGS THEREOF FOR PRODUCING A MEDICAMENT SERVING TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN
USE OF SOMATOSTATIN OR ONE OF THE ANALOGS THEREOF FOR PRODUCING A MEDICAMENT SERVING TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN
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机译:使用生长抑素或其类似物生产用于调节非绝经期妇女卵巢卵泡储备的药物
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摘要
Use of somatostatin (I), or its agonistic analogs (Ia), to prepare a composition for regulating the ovarian follicular reserve in non-menopausal women, especially to reduce exhaustion of the reserve over time. An independent claim is also included for use of an antagonistic analog (Ib) of somatostatin to prepare a composition for accelerating entry of quiescent follicles into growth, in non-menopausal women. ACTIVITY : Gynecological; Antiinfertility; Dermatological; Osteopathic. MECHANISM OF ACTION : Somatostatin agonist; Somatostatin antagonist. Fragments of ovine ovarian cortex were cultured under 5% carbon dioxide, in nutrient medium, and after 10 days only about 10% of the follicles were in the quiescent state while about 65% had developed into primary follicles. When the test was repeated in presence of 10 -6 M somatostatin, about 65% were still quiescent after 10 days and about 15% had developed into primary follicles.
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