MONOCLONAL ANTIBODY, CHIMERIC ANTIBODY, COMPLETELY HUMANIZED ANTIBODY, ANTIBODY TO ANTIIDIOTYPIC ANTIBODY OR FRAGMENT THEREOF TO RECEPTOR OF LIPOPROTEINS OF LOW DENSITY (LPLD) OF HUMAN, A METHOD FOR OBTAINING AND USE THEREOF

摘要

Represented are monoclonal antibodies, chimeric antibodies, completely humanized antibodies, antibodies to antiidiotypic antibodies or fragment thereof, which specifically recognize and bind soluble receptor of lipoproteins of low density (LPLD) of human and fragments thereof, and also able to inhibit replication of virus of hepatitis C. Said antibodies are obtained by immunisation of animals with form of soluble receptor of LPLD of human, which contains amino acid sequence from Asp+4 to Glu+291 of sequence of said receptor. Applied antibodies are suitable for identification and cleaning of LPLD and for the treatment of hepatitis C.