TRICYCLIC COMPOUNDS (VARIANTS), PROCESS FOR THE PREPARATION THEREOF (VARIANTS), PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, PROCESS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITION, METHOD FOR INHIBITING HIV-INTEGRASE USING MENTIONED COMPOUNDS, METHOD FOR TREATMENT HIV-INFECTION OR TREATMENT OF AIDS OR ARC USING MENTIONED COMPOUNDS

摘要

Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. Formula (I). A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of at to N. X is 0, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalenfly attached at any site.