DETECTION OF HUMAN HEPATITIS B VIRUS SURFACE ANTIGEN MUTANTS BY SPECIFIC AMPLIFICATION AND ITS APPLICATION ON GENE CHIP

摘要

THE NOVEL DNA PROBE SEQUENCES FOR DETECTION, BY POLYMERASE CHAIN REACTION, OF HUMAN HEPATITIS B VIRUS SURFACE ANTIGEN MUTANT 145 (GLYCINE TO ARGININE) FROM REUM SAMPLES. AS A DIRECT APPLICATION, THESE SPECIFIC DNA PROBES ARE IMMOBILIZED ON SOLID GLASS SUPPORTS (GENE CHIP) FOR DETECTION OF HUMAN HEPATITIS B VIRUS SURFACE ANTIGEN MUTANT 145 (GLYCINE TO ARGININE) BY FLUORESCENCE.(FIG 1)