NOVEL PHOSPHONOCARBOXYLATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM

摘要

PHOSPHONOCARBOXYLATE COMPOUNDS WHEREIN A PHOSPHONATE GROUP AND A CARBOXYLATE GROUP ARE LINKED TO THE SAME CARBON ATOM AND WHEREIN SAID CARBON ATOM IS ALSO SUBSTITUTED BY HYDROGEN, HALOGEN, A SULFUR CONTAINING RADICAL, AMINO HYDROXY OR SUBSTITUTED OR UNSUBSTITUTED ALKYL AND BY CERTAIN OTHER GROUPS OR WHEREIN THE PHOSPHONATE AND CARBOXYLATE GROUPS ARE LINKED TO A SINGLE CARBON ATOM OF A MONOCYCLIC OR BICYCLIC RING ARE USEFUL IN TREATING OR PREVENTING METABOLIC BOE DISORDERS CHARACTERIZED BY ABNORMAL CALCIUM AND PHOSPHATE METABOLISM SUCH AS A OSTEOPOROSIS, ARTHRITIS, ESPECIALLY RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS. THE INVENTION FURTHER PROVIDES PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF SUCH CONDITIONS INCORPORATING THE NOVEL PHOSPHONO CARBOXYLATE COMPOUNDS OF THE INVENTION.