首页> 外国专利> APPLICATION OF ALFA1BETA1 INTEGRIN RECEPTORINHIBITORS AND TGF-BETA1 INHIBITORS FOR THE TREATMENT OF KIDNEY DISEASES

APPLICATION OF ALFA1BETA1 INTEGRIN RECEPTORINHIBITORS AND TGF-BETA1 INHIBITORS FOR THE TREATMENT OF KIDNEY DISEASES

机译:ALFA1BETA1整合素受体抑制剂和TGF-BETA1抑制剂在治疗肾脏疾病中的应用

摘要

The present invention provides methods for treating (i.e., delaying the onset of, slowing the progression of, and/or reversing) kidney disorders (e.g., renal glomerulonephritis and/or renal fibrosis). Certain of these methods involve administering an .alpha.1.beta.1 integrin receptor inhibitor optionally in combination with a TGF-.beta.1 inhibitor. The present invention also provides a mouse model for kidney disease wherein the mouse does not express a normal collagen type 4 composition in the GBM (i.e., it does not incorporate collagen .alpha.3(IV), .alpha.(IV), and .alpha.5(IV) chains into its glomerular basement membrane) and does not express the .alpha.1.beta.1 integrin receptor.
机译:本发明提供了用于治疗(即,延迟其发作,减慢其发展和/或逆转)肾脏疾病(例如,肾小球肾炎和/或肾纤维化)的方法。这些方法中的某些涉及任选地与TGF-β1抑制剂组合施用α.1.β1整联蛋白受体抑制剂。本发明还提供了一种用于肾脏疾病的小鼠模型,其中所述小鼠在GBM中不表达正常的4型胶原蛋白组合物(即,其不掺入胶原α3(IV),α(IV)和α5(IV)链入其肾小球基底膜),并且不表达α1.β.1整联蛋白受体。

著录项

  • 公开/公告号AT359804T

    专利类型

  • 公开/公告日2007-05-15

    原文格式PDF

  • 申请/专利权人 BOYS TOWN NATIONAL RESEARCH HOSPITAL;

    申请/专利号AT19990923224T

  • 发明设计人 COSGROVE DOMINIC;

    申请日1999-05-19

  • 分类号A61K38/00;A61K39/00;A61K31/445;C12N15/00;A61P13/12;

  • 国家 AT

  • 入库时间 2022-08-21 20:55:10

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