'EMPLOYMENT OF THE GEN SLUG, ITS TRANSCRIPTION OR EXPRESSION PRODUCTS, AND / OR INHIBITING OR STIMULATING COMPOUNDS OF THE SLUG EXPRESSION TO CONFER RADIORESISTENCE OR CELLULAR RADIOPROTECTION.

摘要

The expression of the Slug gene is related to cellular resistance to irradiation since its absence produces an increase in cellular radiosensitivity. Therefore, radiosensitivity can be conferred to tumor cells expressing Slug by repressing its expression or radioprotection can be conferred to normal cells by activating the expression of the Slug gene, its transcription or expression products, thereby producing an increase in the efficacy of the Radiation therapy by reducing, or eliminating, the risk of a possible failure. For application in the treatment of cancer, for example, in the preparation of pharmaceutical compositions that increase the radiosensitivity of tumor cells expressing Slug or pharmaceutical compositions that confer radioprotection or radiosistance to normal cells.