A TRANSDERMAL COMPOSITION OF AN ANTI-VOMITING AGENT AND A PREPARATION OF THE SAME.

摘要

A transdermal composition comprising (a) a matrix containing (i) between 20 and 80% by weight of the hydrophilic organic solvent, (ii) a mixture comprising between 1 and 5% by weight of N, N- diethyl-m-toluamide and between 1 and 5% by weight of glycerin monolaurate as a skin penetration enhancer and (iii) between 15 and 80% by weight of water; and (b) between 1 and 15% by weight, based on the weight of the matrix, of an antiemetic agent selected from the group consisting of tropisetron, ondansetron, granisetron and pharmaceutically acceptable salts thereof.