Platelet Transfusion.

摘要

A method of inhibiting refractoriness Platelet Transfusion THIRD PARTY comprising administering PLAQUETAS A PATIENT WHOSE polypeptides glycoprotein IB (ALFA) PLATELET expressed from the DNA PATIENT HAVE BEEN DETERMINED TO HAVE threonine residues or methionine, or both, at position 145 residue ITS AMINO aCID TAKING SUCH platelets PART EXPRESSED IN POSITION 145 residue polypeptide thereof glycoprotein IB (ALFA) AMINO aCIDS ARE THEMSELVES WHICH THE EXPRESSED ON polypeptides glycoprotein IB (ALFA ) pLATELET PATIENT. Also, an antibody or fragment thereof, in substantially pure form having as its EPITOPE DOMAIN glycoprotein IB (ALFA), the affinity of said antibody or fragment thereof, FOR SUCH EPITOPE BEING DEPENDENT OF IDENTITY OF WASTE AMINO ACID POSITIONS 145 of said glycoprotein. IN ADDITION, IN STORING A SUPPLY OF PLATELET PARAUSO TERAPEUTICO in a patient, the improvement comprises SEGREGATE said platelets PROCESS IN THREE RAINFALL DEPENDING ON WHETHER THE RESIDUAL 145 POLYPEPTIDE IB (ALFA) glycoprotein said platelets includes (a) threonine ( B) mETHIONINE, O (C) BOTH threonine and methionine. Also, an immunoassay method comprising contacting a sample of blood, or a derivative COMPOSITION OF IT WITH FORM THR O MET 145 HALOANTIGENICA glycoprotein IB (ALFA), or a fragment thereof, CONTAINING that position THR / MET145 and determining if present an antibody and a form of said glycoprotein or a fragment thereof.