NUCLEIC AND POLYPEPTIDE ACIDS OF FIBROBLASTIC GROWTH FACTOR 19 (FGF-19) AND PROCEDURES OF USE FOR THE TREATMENT OF OBESITY.

摘要

Use of an FGF-19 polypeptide, or of a nucleic acid encoding an FGF-19 polypeptide, in the preparation of a medicament, in which the medicament is intended for: (a) the treatment of obesity or a related condition with obesity, or (b) reduce the total body mass of an individual and / or reduce the level of fat of an individual, or (c) reduce the level of at least one of triglycerides and free fatty acids of an individual , or (d) increase the metabolic rate of an individual, or (e) induce the release of leptin from fat cells, or (f) induce a reduction in the incorporation of glucose into fat cells, in which the FGF polypeptide -19: (i) comprises the sequence of amino acid residues between 1 or X or 23 ñ 5 to 216 of fig. 2 (SEQ ID No. 2), or a biologically active fragment of the amino acid sequence of fig. 2 (SEQ ID No. 2), or (ii) comprises an amino acid sequence encoded by the human protein cDNA deposited under accession number ATCC 209480, or (iii) consists of the amino acid sequence of fig. 2 (SEQ ID No. 2) without the N-terminal signal sequence and / or without initiation methionine sequence, or (iv) has an amino acid sequence identity of at least 80% with the amino acid sequence of residues 1 or X or 23 ñ 5 to 216 of the amino acid sequence of fig. 2 (SEQ ID No. 2) or with a fragment of the amino acid sequence of fig. 2 (SEQ ID No. 2) and is biologically active; (v) has an amino acid sequence identity of at least 80% with the amino acid sequence encoded by the human protein cDNA deposited under accession number ATCC 209480, and is biologically active, and in which X is between 17 and 27, and the biological activity is one or more of: (1) increase the metabolism or metabolic rate of an individual; (2) reduce the body weight of an individual; (3) reduce the adiposity of an individual; (4) reduce the incorporation of glucose by adipocytes; (5) increase the release of leptin by adipocytes; (6) reduce the level of triglycerides of an individual; and (7) reduce the level of free fatty acids of an individual.