BINDING 3 RET TO STIMULATE NEURAL AND RENAL GROWTH.

摘要

THE PRESENT INVENTION REFERS TO NUCLEOTIDE SEQUENCES CODING A BIND RET (RETL9), AS WELL AS TO THE PROCEDURES FOR STIMULATING NEURAL AND RENAL GROWTH BY TREATMENT OF CELLS AND MAMMAL SUBJECTS WITH DNA OR PROTEIN OF RETL. THE INVENTION PROVIDES AN ISOLATED AND PURIFIED MOLECULA OF DNA CODING A RETL, WHICH HAS THE SEQUENCE OF NUCLEOTIDES OF ANY RETL, BUT SPECIFICALLY INCLUDES THE RETL1 RATL cDNA (SEQ ID NO: 1), THE RETL HUMAN SEQ ID NO: 8), THE HUMAN RETL1 cDNA WITH ALL ITS LENGTH (SEQ ID NO: 10), THE HUMAN RETL2 cDNA (SEQ ID NO: 12), THE MOUSE RETL3 cDNA (SEQ ID NO: 12) OR THE HUMAN RETL3 cDNA (SEQ ID NO: 16), THE PARTIAL HUMAN RETL3 cDNA (SEQ ID NO: 18) OR THE HUMAN RETL3 cDNA (SEQ ID NO: 20). THE INVENTION ALSO PROVIDES A RETL PROTEIN, WITH A SEQUENCE OF AMINO ACIDS THAT INCLUDES THAT OF RETL1 OF THE RAT (SEQ ID NO: 2), THE PARTIAL HUMAN RETL1 (SEQ ID NO: 9), THE HUMAN RETL OF COMPLETE LENGTH (SEQ ID NO: 11), HUMAN RETL2 (SEQ ID NO: 13), MOUSE RETL3 (SEQ ID NO: 17), PARTIAL HUMAN RETL3 (SEQ ID NO: 19) OR HUMAN RETL3 (SEQ ID NO: 21) .