DERIVATIVES OF 2- (AMINOMETIL) -TETRAHIDRO-9-OXA-1,3-DIAZA-CICLOPENTA (A) NAFTALENILO WITH ANTIPSYTIC ACTIVITY.

摘要

Compound of Formula (I) in which: X is H, CF3, alkyl of 1 to 10 carbon atoms, phenyl optionally substituted with one to three substituents independently selected from alkyl of 1 to 10 carbon atoms, -O-alkyl from 1 to 10 carbon atoms, -S-alkyl of 1 to 10 carbon atoms, -CN, -NO2 and halogen; or phenylalkyl of 7 to 9 carbon atoms in which the phenyl ring is optionally substituted by one to three substituents independently selected from hydroxy, amino, halogen, alkyl of 1 to 10 carbon atoms, cyano, nitro, alkylamino of 1 to 10 carbon atoms and dialkylamino of 1 to 10 carbon atoms per alkyl group; R1 is H, alkyl of 1 to 10 carbon atoms, -CH2-cycloalkyl of 3 to 10 carbon atoms, -CH2-bicycloalkyl of 7 to 10 carbon atoms, or - (CH2) mZ-R; R is: m is an integer from 0 to 4; R2 is H or alkyl of 1 to 10 carbon atoms; R3 is H, halogen, alkyl of 1 to 10 carbon atoms, -O-alkyl of 1 to 10 carbon atoms or hydroxy; Z is O, S or ¿CH2-; or R1 and R2 when considered together with the nitrogen atom to which they are attached form a fraction of formula: n is an integer from 1 to 2; R7 and R8 are each independently selected from H, halogen, alkyl of 1 to 10 carbon atoms, -O-alkyl of 1 to 10 carbon atoms and hydroxy; R4 and R5 are independently hydrogen, alkyl of 1 to 10 carbon atoms, -O-alkyl of 1 to 10 carbon atoms, -S-alkyl of 1 to 10 carbon atoms, -CN, -NO2 or halogen; or a pharmaceutically acceptable salt thereof.