N-AROILAMINES CYCLES AS ANTAGONISTS OF OREXIN RECEPTORS.

摘要

A compound of formula (I): in which: X is O, CR7R8, NH or a bond; R1 and R2 are both hydrogen, both optionally substituted (C1-4) alkyl, or together with the carbon to which they are attached form a cycloalkyl (C3-6) ring or a 4- to 6-membered heterocyclyl ring; R3 and R4 are both hydrogen, both optionally substituted (C1-4) alkyl, or together with the carbon to which they are attached form a cycloalkyl (C3-6) ring or a 4- to 6-membered heterocyclyl ring; R7 and R8 are both hydrogen, both optionally substituted (C1-4) alkyl, or together with the carbon to which they are attached form a cycloalkyl (C3-6) ring or a 4- to 6-membered heterocyclyl ring; with the proviso that a pair of R1 and R2, R3 and R4, R7 and R8 are both optionally substituted (C1-4) alkyl, or together with the carbon to which they are attached form a cycloalkyl (C3-6) ring or a 4 to 6-membered heterocyclyl ring, and the rest of the groups are hydrogen; R5 is hydrogen, optionally substituted (C1-4) alkyl, or (C1-4) alkyl optionally substituted CO; Ar1 is an optionally substituted aryl, an optionally substituted mono- or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S; Ar2 represents phenyl, or a 5- or 6-membered heterocyclic group containing up to 3 heteroatoms selected from N, O and S, in which the phenyl or heterocyclyl group is substituted with R6 and other optional substituents; or Ar2 represents an optionally substituted bicyclic or bicyclic heteroaromatic group containing up to 4 heteroatoms selected from N, O and S; R6 represents hydrogen, optionally substituted (C1-4) alkoxy, halogen, cyano, optionally substituted (C1-6) alkyl, optionally substituted phenyl, or an optionally substituted 5 or 6 membered heterocyclyl group containing up to 4 heteroatoms selected from N, O and S; or its pharmaceutically acceptable salt.