GLICOSAMINOGLYCANS, INCLUDING HEPARINASES 1, 2 AND 3, AS WELL AS CONDROITINASAS AC AND B OF THE NEGATIVE GRAM BACTERIA OF FLAVOBACTERIUM HEPARINUM, CAN BE USED WELL SEPARATELY OR IN COMBINATION TO MANIFULATE THE PROMISE. IN ONE VERSION, THE HEPARANISES ARE ADMINISTERED TO DEGRADE THE HEPARAN SULPHATE COMPONENTS OF THE EXTRACELLULAR MATRIX, ALLOWING SO THAT THE GROWTH FACTORS OF THE HEPARINE LINK ARE STORED IN THE EXTRACELLULAR ADULT CELLULAR MATRIX. THE MOBILITY OF CHEMIO-ATTRACTIVE AGENTS, GROWTH FACTORS AND CELLS CAN ALSO BE INCREASED BY TREATING FABRICS WITH DEGRADATION ENZYMES OF GLYCOSAMINOGLYCANS, BOTH CONDROITINAS AND HEPARINASES. THE ENZYMATIC WITHDRAWAL OF THE CONDROITIN SULPHATES OF THE SURFACES OF THE CELLS EFFECTIVELY INCREASES THE CAPACITY OF THE RECEPTORS OF THE GROWTH FACTOR ON THE SURFACE ON THE SURFACE OF THE CELLS. THE SELECTIVE WITHDRAWAL OF HEPARANO SULFATE FROM CELL SURFACES WHILE KEEPING THE EXTRACELLULAR MATRIX INTACTLY, CONVERSIVELY, INHIBITS THE CELLULAR PROLIFERATION THROUGH THE REGULATION AT LOW CELLULAR RESPONSE RESPONSES. THIS IS ACHIEVED BY SENDING THE ACTIVITIES OF DEGRADATION OF HEPARINE OR HEPARAN SULFATE TO THE CELL SURFACE. SENDING THE HEPARINE DEGRADATION ACTIVITY CAN BE ACHIEVED BY GENETIC CONFIGURATION OF A UNION LINK FUNCTIONALITY WITHIN THE HEPARINASE PROTEINS, OR BY PHYSICAL CONTROL OF THE LOCALIZED CONCENTRATION OF ENZYME THROUGH ADMINISTRATION.
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