DIANA CELL CYCLISIS BY SUPERANTIGEN CONJUGATES THAT INDUCE THE ACTIVATION OF T-CELLS.

摘要

The invention relates to a method for inactivating target cells in the presence of T lymphocytes, putting these two cells in contact with a superantigen (SAG) in the presence of an immune modulator. This procedure is characterized in that the superantigen and / or the immune modulator take the form of a conjugate of a "free" superantigen (Sag) and of a fraction that directs this conjugate on target cells. In addition, the invention relates to a superantigen conjugate that responds to formula (I) (T) {sub, x} (Sag) {sub, y} (IM) {sub, z} in which (a) T represents an orientation fraction, Sag, a free superantigen, Im an immune modulator that is not a superantigen - T, Sag and IM being joined by organic B link segments; (b) x, yyz represent whole numbers generally between 0 and 10 and corresponding to the number of fractions of T, Sag and IM, respectively, in a given conjugate molecule, provided that y 0 and that xy / oz 0 The superantigen conjugate is preferably a triple hybrid protein. This invention also relates to an immune modulator characterized in that it is a conjugate of a targeting fraction (T '' '' '') and a modified immune modulator (IM '' '' ''). This conjugate responds to formula (I) except in those referring to the imperative presence of the immune modulator. It may contain a superantigen fraction. Finally, the invention relates to a DNA molecule that encodes a superantigen and an immune modulator.