ANTI-VIRAL AROMATIC O-ALKYLATED OXIMES, ETHERS AND THIOETHERS

摘要

Compounds of the formula(see formula I)wherein Q is (see formula II) or -XR' ;X is oxygen or sulphur;R1 is hydrogen, halogen, C1-C4 alkyl or C1-C4 alkoxy;R2 is hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy,C3-C4 alkenyloxy, C3-C4 alkynyloxy, mono-, di- or tri-halomethyl, trifuluoromethoxy, C1-C4 alkylthio, C3-C4branched alkylthio, nitro, or cyano;R3 is hydrogen or C1-C4 alkyl;R 4 is C3-C6 alkenyl, C3-C6 alkynyl, C1-C8 haloalkyl,C1-C8 alkoxyalkyl, C1-C8 alkylthioalkyl, C1-C8 hydroxyalkyl,C1-C8 acyloxyalkyl, C1-C8 aroyloxyalkyl, C1-C8 carboxyalkyl,C1-C8 alkylcarboxyalkyl, C6-C12 arylcarboxyalkyl, C1-C8aminoalkyl, C1-C8 alkylaminoalkyl, C1-C8 dialkylaminoalkyl,C1-C8 trialkylsilylalkyl, wherein each of theaforementioned alkyl moieties may be straight-chain orbranched; C3-C8 cycloalkyl, C1-C6 alkylphenyl, C7-C12arylalkyl, C7-C12 alkarylalkyl, or heterocyclylalkyl,wherein the heterocyclic moiety is morpholinyl,piperidinyl, pyrrolidinyl, piperazinyl, oxiranyl,oxetanyl, furanyl, tetrahydropyranyl ortetrahydrofuranyl;R' is C1-C8 haloalkyl, C1-C8 alkoxyalkyl, C1-C8alkylthioalkyl, C1-C8 hydroxyalkyl, C1-C8 acyloxyalkyl,C1-C8 aroyloxyalkyl, C1-C8 aminoalkyl, C1-C8alkylaminoalkyl, C1-C8 dialkylaminoalkyl, C1-C8trialkylsilylalkyl, wherein each of the aforementionedalkyl moieties may be straight-chain or branched; C1-C6alkylphenyl, C7-C12 arylalkyl, C7-C12 alkarylalkyl, orheterocyclylalkyl, wherein the heterocyclic moiety ismorpholinyl, piperidinyl, pyrrolidinyl, piperazinyl,oxiranyl, oxetanyl, furanyl, tetrahydropyranyl ortetrahydrofuranyl;R5 is hydrogen, halo, methyl, mono-, di- ortri-halomethyl; andR6 is an aliphatic or cyclic side chain as definedherein.These compounds are useful for inhibiting the growthor replication of retroviruses such as HIV.