NUCLEOTIDE AND AMINO ACID SEQUENCES OF CANINE HERPESVIRUS GB, GC AND GD AND USES THEREFOR

摘要

Disclosed and claimed are nucleotides for genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues. These genesencode polypeptides of 879, 459 and 345 amino acids, respectively, which are also disclosed and claimed. The genes are useful as DNAprobes or, for preparing PCR primers. The polypeptides are useful in antigenic, immunological or vaccine compositions. The nucleotidescan be expressed in any suitable vector system, allowing for production of the polypeptides. Additionally, the vector system containing anyor any combination of the nucleotides can be employed in an antigenic, immunological or vaccine composition, such as a poxvirus vectorsystem, e.g., a CHV-vaccinia or avipox virus recombinant, as can the products from expression, i.e., the gB, gC and gD glycoproteins.Antibodies elicited by the glycoproteins or from expression of the vector containing the nucleotide (s) are also useful. Methods for makingand using the composition are also disclosed and claimed. Also, specific canarypox-CHV gB, gC and gD recombinant vCP 320, vCP322and vCP294 and methods for making and using them are also disclosed and claimed.