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CYCLIC PEPTIDES THAT BIND TO UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR
CYCLIC PEPTIDES THAT BIND TO UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR
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机译:与尿激酶型纤溶酶原激活物受体结合的环肽
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摘要
Cyclic peptide compounds having 11 amino acids joined by a linking unit (L),such that the linear dimension between the C.alpha. carbonof the first amino acid and the C.alpha. carbon of eleventh amino acid isbetween about 4 and 12 .ANG.ngstrom units; are useful for inhibiting thebinding of µPA to the µPAR receptor. Methods for using the cyclicpeptide compounds, and compositions containing them, for inhibitingthe growth or metastasis of cancerous tumors are also disclosed.
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