COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS

摘要

One aspect of the present invention relates to pharmaceutical compositionscontaining two or more active agents that when taken together can be used totreat, e.g., menopause, mood disorders, anxiety disorders, or cognitivedisorders. The first component of the pharmaceutical composition is a sedativeeszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The presentinvention also relates to a method of treating menopause, perimenopause, mooddisorders, anxiety disorders, and cognitive disorders.