2-(IH-THIENO 3,2-C PYRAZOL-3YL)-IH-INDOLE DERIVATIVES AND RELATED COMPOUNDS AS TEC KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS AND IMMUNOLOGICAL DISORDERS

摘要

Disclosed are compounds of formula (I): (F) wherein R1, R2, X and Ar aredefined herein. The compounds ofthe invention inhibit Itk kinase and are therefore useful for treatingdiseases and pathological conditions involving inflammation,immunological disorders and allergic disorders. Also disclosed are processesfor preparing these compounds and to pharmaceuticalcompositions comprising these compounds.