IMMUNOSTIMULATORY COMBINATIONS OF TNFRSF, TLR, NLR, RHR, PURINERGIC RECEPTOR, AND CYTOKINE RECEPTOR AGONISTS FOR VACCINES AND TUMOR IMMUNOTHERAPY

摘要

This invention discloses immunostimulatory combinations of Tumor NecrosisFactor Receptor Superfamily (TNFRSF) agonists, Toll-Like Receptor (TLR)agonists, "domain present in NAIP,CIITA, HET-E, TP-I (NACHT)-Leucine RichRepeat (LRR)" or "NLR" agonists, RIG-I-Like Helicase or "RLH" agonists,purinergic receptor agonists and cytokine/chemokine receptor agonists,together with delivery methods. The combinations, when used alone at the siteof pathology, provide immunostimulation that induces host humoral and cellularimmunologic responses to eliminate pathogens or neoplasms. Alternatively, whenthe combinations are used with a defined antigens, these combinations caninduce focused humoral and cellular immunologic responses useful asprophylactic and/or ameliorative therapeutic modalities for infections and thetreatment of neoplastic disorders.