COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS

摘要

One aspect of the present invention relates to pharmaceutical compositionscontaining two ormore active agents that when taken together can be used to treat, e.g.,menopause, mooddisorders, anxiety disorders, or cognitive disorders. The first component ofthe pharmaceuticalcomposition is a sedative eszopiclone. The second component of thepharmaceuticalcomposition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine ortrans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The presentinvention alsorelates to a method of treating menopause, perimenopause, mood disorders,anxiety disorders,and cognitive disorders.