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COMPOSITIONS OF PROTEIN MIMETICS AND METHODS OF USING SAME AGAINST HIV-1, SARS-COV AND THE LIKE
COMPOSITIONS OF PROTEIN MIMETICS AND METHODS OF USING SAME AGAINST HIV-1, SARS-COV AND THE LIKE
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机译:蛋白质模拟物的组成以及对HIV-1,SARS-COV和类似病毒的使用方法
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摘要
The present invention provides compositions of protein mimetics and methods of using same against HIV-1, SARS-coV and the like. In one aspect, the present invention relates to a protein mimetic for preventing HIV-1 entry to host cells of a living subject through membrane fusion, wherein HIV-1 contains at least one envelope glycoprotein gp41 that has a plurality of peptides in a pre-hairpin state. In one embodiment, the protein mimetic comprises at least two monomeric peptide strands and an interstrand linker coupling the monomeric peptide strands. The coupled monomeric peptide strands prevent the plurality of trimeric gp4l in a pre-hairpin state from transiting to a six-helix hairpin bundle, thereby inhibiting HIV-1 entry to the host cells through membrane fusion.
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