METHODS FOR MEASURING TRANSFORMING GROWTH FACTOR BETA (TGF-ß) RECEPTOR SIGNALING ACTIVITY AND USES THEREOF

摘要

Methods are disclosed for determining the optimal biologic dose of a TGFß receptor kinase inhibitor for administration to patients in need of such therapy and for monitoring the effectiveness of therapy with a TGFß receptor kinase inhibitor in patients receiving such therapy. Kits comprising antibodies and reagents useful in such methods are also disclosed.