SELF-IMMOLATIVE MAGNETIC RESONANCE IMAGING CONTRAST AGENTS SENSITIVE TO BETA-GLUCURONIDASE

摘要

The present invention relates to magnetic resonance imaging (MRI) contrast agent. In particular, the present invention provides MRI contrast agents that are sensitive to the enzyme beta-glucoronidase. The MRI contrast agents provide compositions and methods for non-invasive diagnostic imaging of tissues, including necrotic tumors.