METHODS FOR MAKING COMPOSITIONS COMPRISING HEAT SHOCK PROTEINS OR ALPHA-2-MACROGLOBULIN FOR THE TREATMENT OF CANCER AND INFECTIOUS DISEASE

摘要

The present invention relates to methods for making complexes of HSP or alpha-2 macroglobulin and antigenic peptides, and uses of such complexes for the prevention and treatment of infectious diseases, cancers, and metabolic disorders. The methods of the invention comprises treating a purified target antigen preparation with a protease and/or a chemical to generate an antigenic set of peptides which is complexed to HSP or alpha-2 macroglobulin. Also encompassed in the invention are compositions comprising complexes of HSP or alpha-2 macroglobulin and antigenic peptides.