FULLERENE COMPOSITIONS FOR AMELIORATING HEARING LOSS, COLLATERAL DAMAGE OF CHEMOTHERAPY, OR MUCOSITIS

摘要

This patent discloses a method of ameliorating a hearing loss, collateral damage of chemotherapy, or mucositis in a mammal, comprising administering a composition comprising a substituted fullerene to the mammal afflicted with the hearing loss, collateral damage of chemotherapy, or mucositis or potentially afflicted with the hearing loss, collateral damage of chemotherapy, or mucositis wherein the substituted fullerene comprises a fullerene core (Cn) and at least one of: (i) from 1 to 3 (CXSUP1/SUPXSUP2/SUP) groups bonded to the fullerene core; (ii) from 1 to 18 -XSUP3/SUP groups bonded to the fullerene core; (iii) from 1 to 6 -XSUP4/SUP- groups bonded to the fullerene core; or (iv) from 1 to 6 dendrons bonded to the fullerene core.